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The following is a brief description of how to tune a six string guitar in standard tuning. It is always critical for a guitar to be in tune with itself to sound correct. If it is being played solo, it can be slightly out of tune with standard tuning as long as it is still in tune with itself and still sound correct. If being played with other instruments, it is critical that it be in tune with the other instruments, even if they are out of standard tuning.